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KMID : 0355820190400010061
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Korean Journal of Oral Anatomy
2019 Volume.40 No. 1 p.61 ~ p.68
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Pitx2 expression, an odontogenic band marker in Xenopus laevis
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Ko Byung-Seok
Hong Ji-Soo
Park Byung-Keon
Lee Young-Hoon
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Abstract
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Amphibians are polyphyodonts, which continually replace teeth during their lifetime. Tooth development starts from the dental lamina and the tooth germ goes through the placode, bud, cap, and bell stages. The dental lamina contains stem cells and has been reported to express molecular markers. However, little is known about the molecular markers in the odontogenic band of amphibians. In this study, pitx2 expression in the tooth germ was investigated from 26 days post-fertilization (PF, stage 54) to 41 days PF (stage 57) by using whole mount in situ hybridization in Xenopous laevis. The first tooth germ was formed anterior to the choanae and the tooth germs developed in the mesiodistal direction. Pitx2 was expressed in the odontogenic band from stage 54 onwards and was expressed strongly in the tooth germ at stages 55 and 56. From stage 57, pitx2 was intensely expressed in the round tooth germs and slender odontogenic band but mildly expressed in the triangular tooth germs. These data demonstrate that pitx2 is a marker for the odontogenic band in Xenopus laevis and may play a critical role in the tooth germ induction and formation.
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KEYWORD
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Xenopus laevis, odontogenic band, pitx2 expression
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